Sacred Ground Medicine

Kambo is a highly complex cocktail of bioactive peptides. ‘Bioactive’ here simply means they have a specific biological function within the living organism. So they are recognized by the body as its own and thus unlocks its cells to them instead blocking them as foreign and creating stress and leaving behind a residue. Peptides are short chains of amino acids. A longer chain of amino acids is called a protein. Examples of naturally occurring peptides in the human body include oxytocin, endorphin and insulin. Amino acids are often referred to as the building blocks of all human life. This means that Kambo is made from the same basic ingredients that humans are.

There is a wide array of peptides, neuropeptides and biopeptides that have very specific functions in the human body including neurotransmission, pain relief, anti-inflammation, detoxification, immune system boosting, hormone balance, antibacterial, anti-fungal, anti-parasitic and much more.

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The Kambo frog secretion contains at least 16 bioactive peptides, and there are currently more than 70 patents filed on their analogues. This peptide-rich secretion enters through your lymphatic system, which allows a very rapid distribution to other bodily systems. These compounds increase circulation and sensory perception, influence the release of endorphins, boost the immune system, and have analgesic and anti-inflammatory properties. 

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Much of human diseases can be attributed to inflammation and activation of the stress system. The peptides found in Kambo have been shown to have beneficial effects on autoimmune conditions, killing parasites, lyme disease, fibromyalgia and chronic pain, there is even anecdotal evidence of and regular use among the Amazonian tribal women for its assistance in overcoming infertility as well as enhances libido/fertility in men as a natural side effect of the way it strengthens our immune and circulatory systems.

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Kambo’s many peptides include within them a number of exorphins, which are similar to endorphins, but are produced by amphibians and don’t exist naturally in the human body. Kambo’s effects on our opioid system are more powerful than that of morphine. A number of these effects come from the actions of specific exorphins on your mu-opioid receptors, which can produce pain-relief and a sense of well-being, in part by causing the release of the neurotransmitters serotonin and dopamine. This effect can last long after you take Kambo, because it works to recalibrate and reset your brain’s opioid and serotonergic systems. It’s possible that Kambo’s effects on the brain are so strong because certain peptides increase the permeability of your blood-brain barrier. Another exorphin, deltorphin, binds to your delta opioid receptors, which can also induce pain relief. It may actually prime these receptors to become more sensitive, leading to increased responsiveness of the body's natural opioid system and improvement of certain chronic pain conditions well after you receive Kambo.

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Kambo’s purgative effects likely come from the actions of tachykinin peptides and opioid activation of dopamine pathways affecting the area postrema, your brain’s vomiting center. It’s possible that once you purge, there’s nothing left, and the fat-soluble toxins are bound to bile in your upper and lower GI tract and get excreted. Kambo may even help fight infections, as its dermaseptin peptides can help to reduce bacteria by increasing the activity of white blood cells called lymphocytes.

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Two other peptides from Kambo could also cause your blood vessels to dilate and as a result, your blood pressure will spike and you will feel flushed. When your blood pressure drops back down your gut will release serotonin. Typically, people will feel some discomfort for the 20-30 minutes that the Kambo is taking effect, but then will most likely feel reinvigorated after. As a result of these vasodilating actions, many people with migraines may find that their migraines worsen while sitting with Kambo, but the likelihood of future migraines are significantly reduced following their session.

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Recent scientific studies have been focusing on specific peptides as opposed to the totality of the secretion. Kambo contains peptides that have been shown to kill in vitro cancer cells, peptides that are 30 to 40 times more potent than morphine without any negative side effects, peptides that reduce blood pressure, modify satiety, sedation and thermoregulation, peptides that demonstrate potent antimicrobial activity against bacteria, yeast, fungi, protozoa and enveloped viruses and because Kambo is able to cross the blood-brain barrier, neuropeptides that are active in the central and peripheral nervous system. 

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Kambo Peptides

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The beneficial nature of the peptides in Kambo has led to more than 70 patents being lodged by scientists and pharmaceutical companies, all in the hope that they can replicate the many benefits of Kambo. 

 

The following are 11 well-known peptides that have been isolated in the Kambo secretion. It is a blend that is completely unique to this frog medicine. 

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Phyllocaerulein – a neuropeptide (a special type of peptide that helps neurons communicate in the brain) that reduces blood pressure, modifies satiety (stomach fullness), and manages sedation and thermoregulation. It is also a potent pain killer.

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Phyllokinin – a peptide that reduces blood pressure in the long-term, and crosses the blood-brain barrier to help take Kambo’s benefits to the brain.

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Phyllomedusin – a neuropeptide (unique to Kambo) that acts as a powerful vasodilator, widening and relaxing blood vessels, veins, and arteries.

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Dermorphin – a chain that acts on opioid receptors to reduce pain. It is 30-40 times more potent than morphine.

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Deltorphin – another peptide that interacts with opioid receptors, showing higher selectivity for them than any compound known to man. There are 2 Deltorphins in Kambo, adding to its strong pain-killing properties.

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Dermaseptin – a peptide with potent antimicrobial effects against bacteria, yeast, fungi, protozoa, and even enveloped viruses.

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Adenoregulin – a peptide that has been shown to be very effective in killing cancer cells, effectively turning off their fuel supply.

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Tryptophyllin – a peptide that has been shown to be highly potent against the yeast Candida Albicans.

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Phyllolitorin, [Leu8] Phyllolitorin, Rohdei-Litorin – 3 neuropeptides that stimulate gastric acid secretion and smooth muscle contraction.

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